Drug-Linker Conjugates for ADC
Drug-Linker Conjugates for Antibody Drug Conjugates (ADCs) comprise of an active cytotoxic drug and an appropriate linker. After linked to a monoclonal antibody, those conjugates can be used for making ADCs, which are targeted agents for cancer cells with high selectivity and cytotoxicity.
The drug units in drug-linker conjugates are cytotoxic agents (i.e. ADC cytotoxins or payloads) with antitumor activity and can be classified in DNA damaging agents and tubulin inhibitors. The most commonly used DNA damaging agents in ADCs are Duocarmycins, Pyrrolobenzodiazepines, Camptothecins and Daunorubicins/Doxorubicins, while the popular tubulin inhibitors are Auristatins and Maytansinoids. Besides, there are also many traditional cytotoxic agents can be used in ADCs.
ADC linkers currently undergoing clinical evaluation are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, and noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule.
Drug-Linker Conjugates for ADC Isoform Specific Products
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Drug-Linker Conjugates for ADC
(326)
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Auristatin
(45)
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Camptothecins
(33)
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Daunorubicins/
Doxorubicins (5)View all products
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Duocarmycins
(8)
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Maytansinoids
(19)
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Pyrrolobenzodiazepines
(5)
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Traditional Cytotoxic Agents
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Dual payloads
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Drug-Linker Conjugates for ADC Related Products (499)
Related Products (499)
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Drug-Linker Conjugates for ADC Isoform Comparison
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Desmethyl Vc-seco-DUBA
0 ImagesCat. No.: HY-131085Desmethyl Vc-seco-DUBA consists a cleavable ADC linker (Desmethyl Vc-seco) and a DNA alkylating agent (DUBA). Desmethyl Vc-seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs).
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Acetylene-PEG3-MMAF-OMe
0 ImagesCat. No.: HY-155744CAS No.: 1411977-91-7Synonyms: LCB14-0536Acetylene-PEG3-MMAF-OMe (LCB14-0536) is a protein-active agent conjugate. Acetylene-PEG3-MMAF-OMe can be recognized by isoprenoid transferase. Acetylene-PEG3-MMAF-OMe is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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STING agonist-49-CO-C2-mal
0 ImagesCat. No.: HY-179627CAS No.: 2803607-99-8STING agonist-49-CO-C2-mal (compound ncSTING linker-payload) is a non-cleavable drug-linker conjugate for ADC. STING agonist-49-CO-C2-mal can be used in the synthesis of antibody-drug conjugates (ADCs).
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m-PEG6-Lys-Mal-Toxophore-quinoline
0 ImagesCat. No.: HY-164706CAS No.: 2369100-39-8m-PEG6-Lys-Mal-Toxophore-quinoline is a drug-linker conjugate for ADC and can be used for ADC synthesis. The payload is a NAMPT inhibitor (HY-164760).
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β-Glucuronide-dPBD-PEG6-NH2
0 ImagesCat. No.: HY-181438CAS No.: 2486273-41-8β-Glucuronide-dPBD-PEG6-NH2 is the linker-payload of an antibody-drug conjugate (ADC).
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Mc-Gly-Gly-Phe-Gly-PAB-pSar11-Exatecan
0 ImagesCat. No.: HY-178279CAS No.: 2928560-28-3Mc-Gly-Gly-Phe-Gly-PAB-pSar11-Exatecan (compound L-D-5) is a toxin-linker compound that can be used for the preparation of antibody-drug conjugates (ADCs).
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DGN549-L
0 ImagesCat. No.: HY-145365CAS No.: 1884276-68-9DGN549-L is a DNA alkylator and can be utilized for antibody conjugation at lysine residues. DGN549-L can be used in the synthesis of antibody-drug conjugates (ADCs).
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Amine-PEG8-Val-Cit-PAB-MMAE
0 ImagesCat. No.: HY-164346CAS No.: 2879227-86-6Amine-PEG8-Val-Cit-PAB-MMAE is a potent drug-linker conjugate for antibody-drug conjugates (ADCs).Amine-PEG8-Val-Cit-PAB-MMAE consists of the linker amine-PEG8-Vali-Cit-PAB and the payload MMAE (HY-15162), and can be used to synthesize ADCs. Amine-PEG8-Val-Cit-PAB-MMAE can be used for the research of gastric cancer, colon cancer, lung adenocarcinoma.
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MC-Alkyl-Hydrazine Modified MMAF
0 ImagesCat. No.: HY-128961CAS No.: 1404071-64-2MC-Alkyl-Hydrazine Modified MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the Modified MMAF (a tubulin inhibitor), linked via the noncleavable MC-Alkyl-Hydrazine.
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Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag
0 ImagesCat. No.: HY-158349CAS No.: 2553413-19-5Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag is a drug-linker conjugate for ADC.
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STING agonist-49-PAB-Ala-Val-CO-C2-mal
0 ImagesCat. No.: HY-179660CAS No.: 2803608-03-7STING agonist-49-PAB-Ala-Val-CO-C2-mal, a pep-cSTING linker-payload, is a drug-linker conjugate for ADC. STING agonist-49-PAB-Ala-Val-CO-C2-mal can be used for ADC synthesis.
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Mal-Val-Ala-PAB(C2-glucuronic acid)-DMEA-PNU-159682
0 ImagesCat. No.: HY-132031CAS No.: 2682939-53-1Mal-Val-Ala-PAB (C2-glucuronic acid)-DMEA-PNU-159682 is a drug-linker conjugate composed of a cleavable Val-Ala linker and the potent ADC cytotoxin PNU-159682 (HY-16700), which is applicable for ADC synthesis. When conjugated with an anti-CD46 antibody, Mal-Val-Ala-PAB (C2-glucuronic acid)-DMEA-PNU-159682 delivers its payload to CD46-expressing cells, while cathepsin B cleaves the Val-Ala linker to release the payload. ADCs synthesized from Mal-Val-Ala-PAB (C2-glucuronic acid)-DMEA-PNU-159682 drive durable responses in CD46-expressing patient-derived xenograft models of non-small cell lung cancer and colorectal cancer, and a single administration induces complete tumor regression in most models. Mal-Val-Ala-PAB (C2-glucuronic acid)-DMEA-PNU-159682 can be used in the research of non-small cell lung cancer and colorectal cancer.
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Deruxtecan-d4
0 ImagesCat. No.: HY-13631ESCAS No.: 2760715-91-9Synonyms: MC-GGFG-DXD-d4Deruxtecan-d4 is deuterium labeled Deruxtecan (HY-13631E). Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.
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GGFG-PAB-Exatecan TFA
0 ImagesCat. No.: HY-153069A
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MC-Gly-Gly-Phe-Gly-NH-CH2-O-cyclopropane-CH2COOH
0 ImagesCat. No.: HY-160453CAS No.: 2922606-39-9MC-Gly-Gly-Phe-Gly-NH-CH2-O-cyclopropane-CH2COOH is a camptothecin derivative. MC-Gly-Gly-Phe-Gly-NH-CH2-O-cyclopropane-CH2COOH can be used for antibody drug conjugate (ADC).
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Val-Cit-Exatecan TFA
0 ImagesCat. No.: HY-160756AVal-Cit-Exatecan TFA is an agent-linker conjugate for ADC. Val-Cit-Exatecan TFA is composed of a DNA topoisomerase I Exatecan (HY-13631) and a cathepsin cleavable ADC linker.
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MP-PEG8-Val-Lys-Ala-7-MAD-MDCPT
0 ImagesCat. No.: HY-145943CAS No.: 2639190-44-4MP-PEG8-Val-Lys-Ala-7-MAD-MDCPT is a agent-linker conjugate for antibody-drug conjugate (ADC). MP-PEG8-Val-Lys-Ala-7-MAD-MDCPT has the potential for cancer and autoimmune disease research.
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Mal-VC-PAB-EDA-N-Ac-Calicheamicin
0 ImagesCat. No.: HY-171489CAS No.: 2028299-61-6Mal-VC-PAB-EDA-N-Ac-Calicheamicin is a Drug-Linker Conjugate for ADC with potent antitumor activity. Mal-VC-PAB-EDA-N-Ac-Calicheamicin consists of ADC toxin Calicheamicin (HY-19609) and a linker. Mal-VC-PAB-EDA-N-Ac-Calicheamicin can be used for synthesis of ADC, PF-06647263 (HY-111965).
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Glucocorticoid receptor modulator 4
0 ImagesCat. No.: HY-163673CAS No.: 2688785-30-8Glucocorticoid receptor modulator 4 (Compound DL5) is a conjugate of a linker and a glucocorticoid receptor modulator. Glucocorticoid receptor modulator 4 exhibits GRE Reporter activity in mTNF expressing K562 cell with an EC50 of 40 μM. Glucocorticoid receptor modulator 4 binds with an anti-tumor necrosis factor (TNF) antibody, and exhibits anti-inflammtory activity against arthritis in mouse models.
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MC-GGFG-3-Methylenecyclobutyl-Exatecan
0 ImagesCat. No.: HY-181184CAS No.: 3109352-90-8MC-GGFG-3-Methylenecyclobutyl-Exatecan (Raludotatug-L-1-1) is a conjugate of the toxin molecule Exatecan (HY-13631) and the linker (HY-181185), and it can be used for the synthesis of ADC molecules.
